Komeda diabetes-prone rat developed by Komeda from Long-Evans Tokushima Lean (LETL) rat at Tokyo Medical College in 1996. Komeda non Diabetic Rats were established simultaneusely as controls.
Strain characteristics
KDP rats show 100% development of moderate to severe insulitis within 220 d of age. The cumulative frequency of IDDM was 70% at 120 d of age, and reached 82% within 220 d of age.
Breeding Conditions
Homozygous Iddm/kdp1males are infertile. Homozygous females are fertile but difficult to breed. Maintained by crossing heterozygotes of the Iddm/kdp1 locus.
Genotyping
Cblb mutation is detected by PCR-RFLP.
References
Yokoi N, Hayashi C, Fujiwara Y, Wang HY, Seino S.
Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.
Diabetes. 56(2):506-12, 2007.
Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 31(4):391-4, 2002.
Komeda K, Noda M, Terao K, Kuzuya N, Kanazawa M, Kanazawa Y.
Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats.
Endocr J. 45(6):737-44, 1998.
Yokoi N, Kanazawa M, Kitada K, Tanaka A, Kanazawa Y, Suda S, Ito H, Serikawa T, Komeda K.
A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.
J Clin Invest. 15;100(8):2015-21, 1997.
Embryo 
Sperm 
