網站導覽  
美國WPI產品
 
美國 Taconic Biosciences
 
美國 The Jackson Lab
 
日本IAR實驗動物
 
閉鎖群 Closed Colony
 
遠交系大鼠 Outbred Rat
 
近交系小鼠 Inbred Mouse
 
免疫缺陷小鼠 Immunodeficiency
 
疾病模式大鼠
 
疾病模式小鼠
 
各種實驗動物
 
Tg實驗動物
 
實驗動物特殊飼料
 
日本實驗大鼠、小鼠
 
疾病模式動物
 
 

Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  beige (A,B,hi,bg)
Inbred Generations  F35+F27 (09.5.29)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Lyst: lysosomal trafficking regulator
Origin Spontanious mutation from ACI/NKyo inbred at Kyoto University in 1999.
Strain characteristics This mutant rat shows beige coat color, giant granule cells in various tissues, and prolonged bleeding time. This mutant strain is a disease model for human Chediak-Higashi syndrome (CHS). This mutation is a deletion of about 20 kb containing exons 28, 29 and 30, which constitute the 578 bp sequence missing in the Lyst cDNA on rat chromosome 17. This mutant gene is allelic to Lystbe (DA-beige rat) but the putative deletion break points in L1 elements were different from it (Mori, 2003). The nested PCR-RFLP analysis is useful to discriminate Lystbe-Kyo from Lystbe (Masui, 2004). (09.5.21)
Breeding Conditions Maintained by crossing of homozygoutes. Litter size is small.
Genotyping  
References 山崎賢一、中西聡、北田一博、芹川忠夫、西川哲、並木千晶、浜田修一、橋本敦
ACI/N系統に出現した新たな淡毛色ラットの解析
第68回関西動物実験研究会要旨

Mori M, Yamasaki K, Nakanishi S, Kitada K, Higuchi K, Namiki C, Hamada S, Serikawa T.
A new beige mutant rat ACI/NKyo-Lyst
Exp. Anim. 52(1), 31-36, 2003.

Masui N, Mori M, Nishikawa T, Takagi Y, Asai H, Yanabe M, Yamasaki K, Serikawa T, Sato K.
An allele-specific genotyping method for rat lyst (lysosomal trafficking regulator) gene.
Exp Anim. 2004 53(1):77-80.
Additional strain information ACI

 
 
 
關於太和實驗動物實驗儀器設備飼育管理儀器手術解剖器具美國WPI產品聯絡我們首頁