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Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
Ishibashi rat derived from a cross between a wild male and a Wistar female, with sib mating since 1975 at Azabu University, transferred to Kyoto University in 1978 (IS/Kyo).
Strain characteristics
Malformations of the thoracicolumbar vertebrae leading to kyphoscoliosis with restricted spinal canals and compressed spinal cords. The malformations occur from the 12th. thoracic to the 6th. lumbar vertebrae. Up to 7 vertebrae are affected, and some degree of abnormality occurs in 90% of individuals. The expression levels of Hox10 and Hox11 paralogs, which regulate the formation of lumbar and sacral vertebrae, is extremely low in lumbo-sacral transitional areas of ISR compared with those of normal rats (Seki, 2008). The IS rat shows the low plasma alkaline phosphatase (ALP) activity but there is no relations between the ALP activity and the vertebral anomalies (Maekawa, 1982). (09.6.4)
Breeding Conditions
Good breeding performance. Sib mating.
Genotyping
References
Seki T, Shimokawa N, Iizuka H, Takagishi K, Koibuchi N.
Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats.
Mol Cell Biochem. 312(1-2):193-9, 2008.
Ishibashi M.
Congenital vertebral malformation (Ishibashi rats).
In Handbook on Animal Models of Human Diseases, pp. 430-434, Kawamata J. and Matushita H. (edit.) Ishiyaku Shuppan Ltd. Tokyo. 1979.
Maekawa R, Yamada J, Nikaido H.
Genetical studies of low plasma alkaline phosphatase (ALP) activity in the IS strain of rats.
Jikken Dobutsu. 31:13-19, 1982.
Yamada J, Nikaido H, Moritake S, Maekawa R.
Genetic analyses of the vertebral anomalies of the IS strain of rat and the development of a BN congenic line with the anomalies.
Lab Anim. 16: 40-47, 1982.
Moritake S, Yamamuro T, Yamada J, Watanabe H.
Progression of congenital kyphosis in Ishibashi rats.
Acta Orthop Scand. 54: 841-846, 1983.
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Segregating