The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Japan SLC,Inc.
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
Noda Epileptic Rat derived from Crj: Wistar rats. Developed by A. Noda, 1985. 1997 introduced to Kyoto University (F28).
Strain characteristics
Animal model of epilepsy that exhibit spontaneous tonic-clonic convulsions, beginning with neck and forelimb clonus, wild jumping/running, opisthotonic posturing, and evolving to tonic, then clonic convulsion, followed by postictal flaccidity. Ictal cortical and hippocampal EEGs are characterized by high-voltage spikes followed by diffuse spike-and-wave or polyspike-and-wave complexes. Seizure susceptibility to pentylenetetrazol, tossing, and transcorneal electroshock, but not to tactile, photic, or acoustic stimuli, or to transauricular electroshock. No pathologic changes were demonstrated in the CNS. Spontaneous convulsions are controlled by a major autosomal recessive gene for epilepsy, that are comparable to generalized tonic-clonic seizures in humans (Noda et al. 1998).
Breeding Conditions
Good breeding performance.
Genotyping
References
Maihara, T., Noda, A., Yamazoe, H., Voigt, B., Kitada, K. and Serikawa, T.
Chromosomal mapping of genes for epilepsy in NER: A rat strain with tonic-clonic seizures.
Epilepsia, 41 (8): 941-949, 2000.
Sejima, H., Ito, M., Kishi, K., Noda, A. and Serikawa, T.
Regional excitatory and inhibitory amino acid concentrations in Noda epileptic rat (NER) brain.
Brain Develop, 21: 382-385, 1999.
Jinde, S., Masui, A., Morinobu, S., Takahashi, Y., Tsunashima, K., Noda, A., Yamada, N. and Kato, N.
Elevated neuropeptide Y and corticotropin-releasing factor in the brain of a novel epileptic mutant rat: Noda epileptic rat.
Brain Res., 30 (2): 115-126, 1999.
Iida, K., Sasa, M., Serikawa, T., Noda, A., Ishihara, K., Akimitsu, T., Hanaya, R., Arita, K. and Kurisu, K.
Induction of convulsive seizures by acoustic priming in a new genetically defined model of epilepsy (Noda epileptic rat: NER).
Epilepsy Res, 30 : 115-126, 1998
Noda, A., Hashizume, R., Maihara, T., Tomizawa, Y., Ito, Y., Inoue, M., Kobayashi, K., Asano, Y., Sasa, M., Serikawa, T.
NER rat strain, a new type of genetic model in epilepsy research.
Epilepsia, 39 (1): 99-107, 1998.
Sasa、M.,Hanaya, R., Iida, K., Akimitsu, T., Kurisu, K., Noda, A., Kobayashi, K., Asano, Y., Sasa, M. and Serikawa, T.
A novel epilepsy animal model (NER).
Nihon Shinkei Seishin Yakurigaku Zasshi, 17(1): 35-38, 1997 (in Japanese)