Rab38: Rab38, member of RAS oncogene family. ruby or red eyed dilution
Origin
Tester Moriyama rat derived from Long-Evans at Aichi Cancer Center, were transferred to Moriyama Mental Disease Hospital and Nagoya University. Inbred Line was established at Nagoya University. From Shionogi & Co., Ltd. to Kyo in 1976 .
Strain characteristics
Used as caot color tester line modified blood caogulation and platelet derived serotonin release was detected. Used as an animal model for platelet storage pool deficiency. TM has a Met1Ile mutation at the translation initiation codon of the Rab38 gene. This mutation is shared with FH rat, showing similar phenotypes to TM rats.
Breeding Conditions
Good breeding performance. Sib mating.
Genotyping
References
Hamada, S., Serikawa, T., Yamada, J.
TMラットの止血時間延長に関する遺伝学的検索
第32回日本実験動物学会総会講演要旨集． p117, 1985
Hamada, S., Nishikawa, T., Yokoi, N., Serikawa, T.
TM rats: a model for platelet storage pool deficiency.
Exp. Anim., 46(3): 235-239, 1997
Fujimori et al., Characterization of platelet abnormalities of Teter Moriyama (TM) rats with strage pool deficiency.
Lab Anim Sci 48(5):490-495,1988.
Oiso, N., Riddle, SR., Serikawa, T., Kuramoto, T., Spritz, RA.
The Rat Ruby (R) Locus is Rab38: Identical Mutations in Fawn-Hooded and Tester-Moriyama Rats Derived from an Ancestral Long Evans Rat Sub-Strain.
Mamm Genome 15(4):307 - 314, 2004
Embryo .JPG)
.JPG)
Segregating