Tremor Rat which was found in a colony of outbred Wistar/Kyo in 1980 was separated to Tanabe Seiyaku Co., Ltd. in 1982.
Strain characteristics
vacuole formation. Segregating inbred strain.
Breeding Conditions
Homozygous infertility. Maintained in heterozygous condition.
Genotyping
Genomic deletion of Aspa gene is detected by PCR.
References
Yamada J, Serikawa T, Ishiko J, Inui T, Takada H, Kawai Y and Okaniwa A.
Rats with congenital tremor and curled whiskers and hair.
Jikken Dobutsu, 34: 183-188, 1985.
Serikawa T, Ohno Y, Sasa M, Yamada J and Takaori S.
A new model of petit mal epilepsy: spontaneous spike and wave discharges in tremor rats.
Lab Anim, 21: 68-71, 1987.
Kitada K, Akimitsu T, Shigematsu Y, Kondo A, Maihara T, Yokoi N, Kuramoto T, Sasa M and Serikawa T.
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
J Neurochem, 74: 2512-2519, 2000.
Embryo .JPG)
.JPG)
Inbred