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Preservation Status:   Embryo        Sperm       Living Animals  
Coat Color  black hooded (a,B,C,h)
Inbred Generations  F27+20
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability Japan SLC,Inc.  
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Cblb: Casitas B-lineage lymphoma b
Origin Komeda diabetes-prone rat developed by Komeda from Long-Evans Tokushima Lean (LETL) rat at Tokyo Medical College in 1996. Komeda non Diabetic Rats were established simultaneusely as controls.
Strain characteristics KDP rats show 100% development of moderate to severe insulitis within 220 d of age. The cumulative frequency of IDDM was 70% at 120 d of age, and reached 82% within 220 d of age.
Breeding Conditions Homozygous Iddm/kdp1males are infertile. Homozygous females are fertile but difficult to breed. Maintained by crossing heterozygotes of the Iddm/kdp1 locus.
Genotyping Cblb mutation is detected by PCR-RFLP.
References Yokoi N, Hayashi C, Fujiwara Y, Wang HY, Seino S.
Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.
Diabetes. 56(2):506-12, 2007.

Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 31(4):391-4, 2002.

Komeda K, Noda M, Terao K, Kuzuya N, Kanazawa M, Kanazawa Y.
Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats.
Endocr J. 45(6):737-44, 1998.

Yokoi N, Kanazawa M, Kitada K, Tanaka A, Kanazawa Y, Suda S, Ito H, Serikawa T, Komeda K.
A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.
J Clin Invest. 15;100(8):2015-21, 1997.
Additional strain information KDP   

 
 
 
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