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Preservation Status:   Embryo        Sperm       Living Animals    
Coat Color  albino (c)
Inbred Generations  N11
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected  
Origin A congenic strain with the genetic background of the BB/WorTky strain (RT1.Bu,Du) onto which the MHC locus of PVG.R23 strain (RT1.Ba,Da) has been transferred.
Strain characteristics Animals carrying u/u alleles of the MHC locus show diabetes and animals carrying a/a alleles show thyroiditis.
Breeding Conditions Maintained by crossing heterozygotes u/a allele of the MHC locus.
Genotyping PCR-RFLP
References Awata T, Guberski DL, Like AA.
Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II.
Endocrinology. 1995 Dec;136(12):5731-5.
Additional strain information BB PVG  

 
 
 
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