The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITOR.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Gulo: gulonolactone (L-) oxidase
Origin
A congenic strain developed from a recipient, SHR(Spontaneously Hypertensive Rat) and a donor, ODS (Lack of L-gulono-gamma-lactone oxidasestrainin). Introduced to Nagoya University in 1995 (now F18).
Strain characteristics
The osteogenic disorder Shionogi (ODS) rat is a mutant Wistar rat that is subject to scurvy, because it lacks L-gulono-gamma-lactone oxidase, a key enzyme in L-ascorbic acid biosynthesis (Horio et al. 1985)
Breeding Conditions
Normal breeding when L-ascorbic acid is supplemented in food (1000mg/kg) or water (1g/L). Breeding performance is unclear post 3rd delivery.
Genotyping
PCR-RFLP
References
Horio F, Hayashi K, Mishima T, Takemori K, Oshima I, Makino S, Kakinuma A, Ito H.
A newly established strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis.
Life Sci. 2001 Sep 7;69(16):1879-90.
Kawai K, Ito H, Kubota H, Takemori K, Makino S, Horio F.
Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid.
Life Sci. 2003 Feb 28;72(15):1717-32.
Embryo .jpg)
.jpg)
Inbred