網站導覽  
美國WPI產品
 
美國 Taconic Biosciences
 
美國 The Jackson Lab
 
日本IAR實驗動物
 
閉鎖群 Closed Colony
 
遠交系大鼠 Outbred Rat
 
近交系小鼠 Inbred Mouse
 
免疫缺陷小鼠 Immunodeficiency
 
疾病模式大鼠
 
疾病模式小鼠
 
各種實驗動物
 
Tg實驗動物
 
實驗動物特殊飼料
 
日本實驗大鼠、小鼠
 
疾病模式動物
 
 

Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  a,B,C,h
Inbred Generations  F13+26 (09.5.29)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Unc5c: unc-5 homolog C (C. elegans)
Origin HOB rat was identified in the F344 congenic rats (N12F13) to which the coat color locus (C) of fatty rat has been transferred in Sankyo Co., Ltd. Introduced to Kyoto University in 1999 at F13.
Strain characteristics Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus.
Breeding Conditions Maintained in sib mating between hob/+ male and hob/hob female. Good breeding performance.
Genotyping PCR-RFLP(see Kuramoto et al. Mol. Brain Res. 122(2): 103-108, 2004)
References Kuwamura M, Ando Y, Takeda A, Kanehara T, Yamane J, Kotani T, Takeshita S, Kanbori M, Kitada, K, Serikawa, T.
Rat mutations cvd and hob with cerebellar malformations map to chromosome 2.
Exp. Anim. 53(1): 21-26, 2004.

Kuramoto T, Kuwamura M, Serikawa T.
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Brain Res Mol Brain Res. 122(2): 103-108, 2004.
Additional strain information HOB   

 
 
 
關於太和實驗動物實驗儀器設備飼育管理儀器手術解剖器具美國WPI產品聯絡我們首頁