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Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  gray
Inbred Generations  F25+?+16 (09.5.29)
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested (*).
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability  
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Myo5a: myosin Va
Origin Founded from a breeding colony of Wistar by Ohno at Yagi Memorial Park in 1988. A congenic line BN-dop and an inbred line DOP-dop were established.
Strain characteristics Normal behaviour until day 10, thereafter, excessive spinning around on smooth surfaces and tendency to be off balance. Slight convulsive limb movements. Can't regain upright posture. Limb convulsion associated with opisthotonus becomes tetanic. Hyperacuety. Dead after 3 weeks. Lighter coat color pigmentation. Controlled by an autosomal recessive gene (Dekker-Ohno et al. 1993).
Breeding Conditions Maintained by crossing heterozygotes of the dop locus (segregating inbred strain).
Genotyping  
References * Dekker-Ohno K, Oda S, Yamamura H, Kondo K.
An ataxic mutant rat with dilute coat color.
Lab Anim Sci. 1993 Aug;43(4):370-2

* Futaki S, Takagishi Y, Hayashi Y, Ohmori S, Kanou Y, Inouye M, Oda S, Seo H, Iwaikawa Y, Murata Y.
Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus.
Mamm Genome. 2000 Aug;11(8):649-55.

* Dekker-Ohno K, Hayasaka S, Takagishi Y, Oda S, Wakasugi N, Mikoshiba K, Inouye M, Yamamura H.
Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat.
Brain Res. 1996 Apr 1;714(1-2):226-30

* Miyata M, Finch EA, Khiroug L, Hashimoto K, Hayasaka S, Oda SI, Inouye M, Takagishi Y, Augustine GJ, Kano M.
Local calcium release in dendritic spines required for long-term synaptic depression.
Neuron. 2000 Oct;28(1):233-44
Additional strain information DOP   

 
 
 
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