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Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  N7F9
Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected  
Origin ACI/N rats are susceptible and BUF/Nac rats are resistant to MNNG-induced stomach carcinogenesis, and the presence of an autosomal gene with a dominant BUF allele has been suggested. By using ACI x (ACIxBUF)F1 backcross rats, one dominant susceptibility gene, Gcs1 (Gastric cancer susceptibility gene 1), and three dominant resistance genes, Gcr1 (Gastric cancer resistance gene 1), Gcr2, and Gcr3 have been mapped by QTL analysis for MNNG-induced stomach carcinogenicity. This congenic strain is homozygous for the ACI/N Gcr1b allele (on chr.4) on the BUF/Nac background.
Strain characteristics  
Breeding Conditions Good breeding performance.
Genotyping D4Rat226, D4Rat109
References Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T, Nagao M.
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer Res, 60:1092-1096, 2000
Additional strain information BUF ACI  

 
 
 
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