In publishing, a citation of the following literature(s) (*) designated by the DEPOSITOR is requested.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Atrn: attractin
Origin
The myelin vacuolation (mv) rats showing body tremor were found in an outbred colony of Sprague-Dawley rats at Osaka Osaka Prefecture University in 1999.
Strain characteristics
The tremor behavior was exhibited from around 3 weeks of age and inherited as an autosomal recessive trait. The mutant rats had variously sized vacuoles in the neuropil and white matter throughout the central nervous system, especially in the brain stem, cerebellum, and spinal cord. Ultrastructurally these vacuoles mainly consisted of splitting of myelin lamella both in the periaxonal and intermyelinic spaces. No abnormality was found in the number and morphology of oligodendrocytes in MV rats, although the severity and extent of myelin disorder increased with age. Coincident with the myelin abnormalities, there was progressive astrogliosis from 2 weeks. Marked microglial activation was observed exclusively in the gray matter of MV rats from 6 weeks, coincident with severe myelin disruption. Genetic studies revealed 6.914-bp deletion including the whole exon 1 of the attractin (Atrn) gene in MV rats and Northern blot analysis showed no expression of Atrn mRNA in the brain of MV rats. Therefore, the MV rat is a null mutation of the Atrn gene. (09.3.4)
Breeding Conditions
Although affected rats are fertile for both sexes, it is recommended to use heterozygous males and females for mating.
Genotyping
References
* Kuwamura M, Maeda M, Kuramoto T, Kitada K, Kanehara T, Moriyama M, Nakane Y, Yamate J, Ushijima T, Kotani T, Serikawa T.
The myelin vacuolation (mv) rat with a null mutation in the attractin gene.
Lab Invest. 2002 Oct;82(10):1279-86.
* Tokuda S, Kuramoto T, Serikawa, T.
PCR-based genotyping of the rat Atrn mutation.
Exp Anim 53(1): 73-76, 2004.
Izawa T, Takenaka S, Ihara H, Kotani T, Yamate J, Franklin RJ, Kuwamura M.
Cellular responses in the spinal cord during development of hypomyelination in the mv rat.
Brain Res. 2008 Feb 21;1195:120-9.
Embryo 
Inbred