In publishing, an acknowledgment to the DEPOSITOR is requested
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Tg: thyroglobulin
Origin
The WIC-rdw rat, established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive.
Strain characteristics
A convincing line of evidence is being developed that the congenital nongoitrous hypothyroidism and dwarfism observed in the WIC-rdw rat may indeed be caused by a primary defect in thyroid hormonogenesis. In support of this hypothesis, several recent reports have shown the presence of elevated molecular chaperone levels in the WIC-rdw thyrocytes, the endoplasmic reticulum of which was markedly dilated, suggesting a defect in intracellular protein transport. It was reported that A missense mutation, G2320R, in the Tg gene is responsible for the rdw mutation in the WIC-rdw rat.
Breeding Conditions
Homozygous rdw rats are infertile in both sexes. So, the mutant rats are maintained as a segregating inbred strain.
Genotyping
References
Shibayama K, Ohyama Y, Ono M, Furudate S
Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J Endocrinol. 138: 307-313, 1993.
Ono M, Harigai T, Furudate S.
Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism.
J. Endocrinol. 143, 479-487, 1994.
Oh-Ishi M, Omori A, Kwon JY, Agui T, Maeda T, Furudate S.
Detecion and identication of proteins related to the hereditary dwarfism of the rdw rat.
Endocrinology 139(3): 1288-1299, 1998.
Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T
A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat.
Endocrinology 141 (11): 4050-4055, 2000.
Sakai Y, Yamashina S, Furudate S
Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in
the thyroid gland of rdw rats with hereditary dwarfism.
Anat Rec 259: 60-66, 2000.
Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S, Agui T
A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat.
Mol Endocrinol 14 (12): 1944-1953, 2000.
Embryo 
Living Animals
