網站導覽  
美國WPI產品
 
美國 Taconic Biosciences
 
美國 The Jackson Lab
 
日本IAR實驗動物
 
閉鎖群 Closed Colony
 
遠交系大鼠 Outbred Rat
 
近交系小鼠 Inbred Mouse
 
免疫缺陷小鼠 Immunodeficiency
 
疾病模式大鼠
 
疾病模式小鼠
 
各種實驗動物
 
Tg實驗動物
 
實驗動物特殊飼料
 
日本實驗大鼠、小鼠
 
疾病模式動物
 
 

Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  
Inbred Generations  F15+13 (08.5.30)
Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Tg: thyroglobulin
Origin The WIC-rdw rat, established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive.
Strain characteristics A convincing line of evidence is being developed that the congenital nongoitrous hypothyroidism and dwarfism observed in the WIC-rdw rat may indeed be caused by a primary defect in thyroid hormonogenesis. In support of this hypothesis, several recent reports have shown the presence of elevated molecular chaperone levels in the WIC-rdw thyrocytes, the endoplasmic reticulum of which was markedly dilated, suggesting a defect in intracellular protein transport. It was reported that A missense mutation, G2320R, in the Tg gene is responsible for the rdw mutation in the WIC-rdw rat.
Breeding Conditions Homozygous rdw rats are infertile in both sexes. So, the mutant rats are maintained as a segregating inbred strain.
Genotyping  
References Shibayama K, Ohyama Y, Ono M, Furudate S
Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J Endocrinol. 138: 307-313, 1993.

Ono M, Harigai T, Furudate S.
Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism.
J. Endocrinol. 143, 479-487, 1994.

Oh-Ishi M, Omori A, Kwon JY, Agui T, Maeda T, Furudate S.
Detecion and identication of proteins related to the hereditary dwarfism of the rdw rat.
Endocrinology 139(3): 1288-1299, 1998.

Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T
A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat.
Endocrinology 141 (11): 4050-4055, 2000.

Sakai Y, Yamashina S, Furudate S
Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in
the thyroid gland of rdw rats with hereditary dwarfism.
Anat Rec 259: 60-66, 2000.

Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S, Agui T
A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat.
Mol Endocrinol 14 (12): 1944-1953, 2000.
Additional strain information WIC   

 
 
 
關於太和實驗動物實驗儀器設備飼育管理儀器手術解剖器具美國WPI產品聯絡我們首頁