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Preservation Status:   Embryo        Sperm       Living Animals    
Coat Color  albino (c)
Inbred Generations  F14+9 (04.3.22)
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Gja8: gap junction membrane channel protein alpha 8
Origin The UPL rat was founded as a mutant with cataracts in a colony of Crj:CD (SD) rats at Tsukuba Research Laboratory, Upjohn Pharmaceuticals Limited, (Ibaraki, Japan) in 1989 and was introduced to the research facilities for laboratory animal science at Hiroshima University School of Medicine in 1996. Upjohn Pharmaceuticals Limited (UPL) rat. (09.3.3)
Strain characteristics Genetic analysis of the mutant showed that a single gene was semidominantly involved in the development of cataract. Homozygotes of UPL rats displayed early-onset cataract, which manifested as lens opacification before eye opening at 14 days of age and was often accompanied by microphthalmos and/or buphthalmos. Heterozygotes of UPL rats displayed late-onset cataract that started to appear at 2 to 4 weeks of age and developed into complete opacity of the lenses in both eyes (mature cataract) at 7 to 8 weeks of age. A candidate gene for formation of cataracts in UPL rats was mapped to rat chr 2, and a missense mutation (R340W) of the Cx50 (Gja8) gene was a strong candidate (Yamashita, 2002). (09.3.3)
Breeding Conditions Maintained by rotation breeding of 3 groups (group A, B and C). Resulting heterozygoutes are used for breeding. Offspring born from group A×B are defined as group C, group B×C are defined as group A, group C×A are defined as group B.
Genotyping  
References Yamashita S, Furumoto K, Nobukiyo A, Kamohara M, Ushijima T, Furukawa T.
Mapping of A gene responsible for cataract formation and its modifier in the UPL rat.
Invest Ophthalmol Vis Sci. 43(10):3153-9, 2002.

http://www.anim.med.kyoto-u.ac.jp/model/sonota/UPL.htm
Additional strain information UPL   

 
 
 
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