Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITEOR.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
In 2001, abnormal incisors that had deteriorated and had a whitish chalk-like appearance were unexpectedly discovered in one male rat among Sprague-Dawley [Crj:CD(SD)IGS] rats (Masuyama, 2005). After that, this mutant phenotype was maintained by sib-mating. (09.11.4)
Strain characteristics
White, chalk-like abnormal incisors. The whitich chalk-like teeth (wct) mutation maps to rat chromosome 14 between D14Got13 and D14Wox2 (Masuyama, 2005).
Breeding Conditions
normal (+/-) × mutant (-/-). Sib mating.
Genotyping
References
Masuyama T, Miyajima K, Ohshima H, Osawa M, Yokoi N, Oikawa T, Taniguchi K.
A novel autosomal-recessive mutation, whitish chalk-like teeth, resembling amelogenesis imperfecta, maps to rat chromosome 14 corresponding to human 4q21.
Eur J Oral Sci. 2005 Dec;113(6):451-6.
Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H.
Rat wct mutation prevents differentiation of maturation-stage ameloblasts resulting in hypo-mineralization in incisor teeth.
Histochem Cell Biol. 2007 Sep;128(3):183-93.
Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H.
Rat wct mutation induces a hypo-mineralization form of amelogenesis imperfecta and cyst formation in molar teeth.
Cell Tissue Res. 2007 Oct;330(1):97-109.
Embryo 
Inbred