In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
Congenic BB.LL rats were established as speed-congenics by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats and marker-aided selection in 1997.
Strain characteristics
Animals are not hypertensive, but deleop a incomplete metabolic syndrome with obesity, hyperleptinemia and dyslipidemia. About 70% of animals are prone to apoplectic stroke.
Breeding Conditions
Genotyping
References
Kloting, I., Kovacs, P. and B. Kuttler
Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat.
Biochem. Biophys. Res. Commun. 239, 106-110, 1997.
Kovacs P, van den Brandt J, Bonne AC, van Zutphen LF, van Lith HA, Kloting I.
Congenic BB.SHR rat provides evidence for effects of a chromosome 4 segment (D4Mit6-Npy approximately 1 cm) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet.
Metabolism. 2001 50(4):458-62.
Kloting I, Kovacs P. and van den BrandtJ
Congenic BB.SHR (D4Mit6-Npy-Spr) rats: A new aid to dissect the genetics of obesity.
Obes Res. 2002 10(10):1074-7.
Lucke S, Kloting I, Pusch A, Heinrich HW and Hahn HJ
Endocrine pancreas histology of congenic BB-Rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X.
Autoimmunity. 2003 36(3):143-9.
Embryo 
Sperm 