In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
1981 outbred animals from Bio Breeding Laboratories, Ottawa, Canada ---> Karlsburg,selection of RT1u and RT1a homozygous animals which separately inbred and known as WOK.1W and WOK.1A.In 1995 there were reproduction problems. The phenotypic characterisation indicated that these animals develop facets of the metabolic syndrome.
Strain characteristics
Male and female WOKW rats develop a polygenetically inherited and complete metabolic syndrome with obesity, hyperinsulinemia and insulin resistance, hyperleptinemia, dyslipidemia, hypertension, impaired glucose tolerance (iGT) and proteinuria.
Breeding Conditions
Genotyping
References
Kloting I, Voigt B. and L Vogt.
Molecular analysis of diabetes-prone BB rat sublines and derivatives of their common ancestor as a tool to search for candidate loci causing different phenotypes in BB rats.
Diabetes Res. 29, 65-71, 1995.
Kovács P, van den Brandt J, Klöting I.
Genetic dissection of the syndrome X in the rat.
Biochem Biophys Res Commun. 269(3):660-5, 2000.
van den Brandt J, Kovács P, Klöting I.
Features of the metabolic syndrome in the spontaneously hypertriglyceridemic Wistar Ottawa Karlsburg W (RT1u haplotype) rat.
Metabolism. 49(9):1140-4, 2000.
Schreyer S, Ledwig D, Rakatzi I, Klöting I, Eckel J.
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
Endocrinology. 144(4):1211-8, 2003.
Kovács P, Voigt B, Berg S, Vogt L, Klöting I.
WOK.1W rats. A potential animal model of the insulin resistance syndrome.
Ann N Y Acad Sci. 20;827:94-9, 1997.
Embryo 
Inbred