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Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others F?+1+2 (09.5.29)
Control Strain
Marker Strain
Gene Affected
Kcnq1: potassium voltage-gated channel, subfamily Q, member 1
Origin
Rats with abnormal behaviors such as head-tossing, drawing back, stepping back, and circling were discovered in the N12F10 generation of a WTC.ZI-Atrnzi congenic strain at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, in 1999. The WTC-Kcnq1dfk/Kyo rat is a mutant for circling behavior. although the Atrnzi allele of WTC.ZI-Atrnzi congenic rats was eliminated, the circling behavior remained.
Strain characteristics
Abnormal behaviors such as head-tossing, drawing back, stepping back, and circling. Complete deafness. Inner ear of the WTC-dfk rats showed collapsed endolymph. Prolonged QT interval in the electrocardiogram (ECG) Gastric achlorhydria associated with hypertrophic gastric mucosa.
Breeding Conditions
Both male and female rats are fertile.
Genotyping
References
Gohma H, Kuramoto T, Kuwamura M, Okajima R, Tanimoto N, Yamasaki K, Nakanishi S, Kitada K, Makiyama T, Akao M, Kita T, Sasa M, Serikawa T.
WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions.
Physiol Genomics. 14;24(3):198-206, 2006.
Kuwamura M, Okajima R, Yamate J, Kotani T, Kuramoto T, Serikawa T.
Pancreatic Metaplasia in the Gastro-achlorhydria in WTC-dfk Rat, a Potassium Channel Kcnq1 Mutant.
Vet Pathol. 45(4):586-91, 2008.
Embryo 
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