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Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  N17F20 (09.5.29)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 放射線感受性
 Control Strain  Marker Strain
Gene Affected  
Origin LEC rats which had high X-ray susceptibility were backcrossed to F344. In every generation, highly X-ray susceptible rats were selectied with the radiation susceptibility assay. 2 strains (F344.LEC-xhs1/1Nrs (NBRP No.0293) and F344.LEC-xhs1/2Nrs (NBRP No.0294)) were established in N17.
Strain characteristics  
Breeding Conditions  
Genotyping  
References Tsuji AB, Sugyo A, Sudo H, Sagara M, Ishikawa A, Ohtsuki M, Kimura T, Ogiu T, Miyagishi M, Taira K, Imai T, Harada YN.
Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4.
Genomics. 2006 Feb;87(2):236-42.

Tsuji AB, Sugyo A, Ogiu T, Sagara M, Kimura T, Ishikawa A, Sudo H, Ohtsuki M, Aburatani H, Imai T, Harada YN.
Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines.
Genomics. 2005 Sep;86(3):271-9.

Ogiu T, Nishimura M, Watanabe F, Ukai H, Ishii-Ohba H, Shimada Y, Tsuji H, Sakurai J, Hino O.
Absence of linkage between radiosensitivity and the predisposing atp7b gene mutation for heritable hepatitis in the LEC rat.
Radiat Res. 2000 Jul;154(1):113-6.
Additional strain information LEC   

 
 
 
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