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  Hos:HR-1 Hairless mice

 

Proper name

Hos:HR-1

Description

同型合子突變(Hrhr/Hrhr),第一毛髮週期正常生長,二週齡因第二毛髮週期異常,開始快速掉毛。離乳期(約三週齡)完全無毛。

 Homozygous mutants (Hrhr/Hrhr) show normal development of the first hair coat (first hair cycle). Starting at 2 weeks of age, they lose their hair coat rapidly and completely due to an abnormal second hair cycle [1, 2]. At weaning (~3 weeks of age), they are completely hairless [3].

Appearance

albino, without hair, unaffected

Genotype

Hrhr/Hrhr
an insertion mutation in intron 6 of mutant Hr genes [3]

Reseach

- 皮膚醫學、傷口癒合模式、安全性與功效性測試

- 類似異位性皮膚炎乾性皮膚無毛鼠的搔抓反應

- 發炎型粉刺小鼠模型

- 光化學皮膚微核試驗

- 光化學基因毒性

* dermatology, wound healing model, safety and efficacy testing

* scratching response of hairless mice with atopic dermatitis-like dry skin    HR-AD diet

* inflammatory acne mouse model [4]

* photochemical skin micronucleus test [5]

* photochemical genotoxicity [5]

Development

 The hairless mutation (Hrhr) was found at Sandra Biological Supply in New York City in 1968. It was brought to Temple University and crossed to CBA mice. These mice were named Skh:HR. We received non-alvino Skh:HR mice and generated homozygous albino animals that are segregating for the hairless phenotype. We named these mice Hos:HR-1.

Attention

Breeding is prohibited.

 

Reference

[1] Brooke, H.C. 1926. Hairless mice. J. Hered. 17, 173–174.

[2] Sundberg, J. P. & King, L. E. Morphology of hair in normal and mutant laboratory mice. Eur. J. Dermatol. 11, 357–61

[3] Suzuki, O., Koura, M., Noguchi, Y., Uchio-Yamada, K. & Matsuda, J. Zygosity determination in hairless mice by PCR based on Hr(hr) gene analysis. Exp. Anim. 62, 267–73 (2013).

[4] Jang, Y. H., Lee, K. C., Lee, S.-J., Kim, D. W. & Lee, W. J. HR-1 Mice: A New Inflammatory Acne Mouse Model. Ann. Dermatol. 27, 257–64 (2015).

[5] Hara, T. et al. In vivo photochemical skin micronucleus test using a sunlight simulator: detection of 8-methoxypsoralen and benzo[a]pyrene in hairless mice. Mutat. Res. 631, 1–8 (2007).

 

 
 
 
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