網站導覽  
美國WPI產品
 
體外受精IVF與生殖工程
 
實驗動物特殊飼料
 
日本IAR實驗動物
 
美國 The Jackson Lab
 
美國 Taconic Biosciences
 
近交系小鼠 Inbred Mouse
 
免疫缺陷小鼠 Immunodeficiency
 
疾病模式大鼠
 
疾病模式小鼠
 
各種實驗動物
 
Tg實驗動物
 
遠交系大鼠 Outbred Rat
 
閉鎖群 Closed Colony
 
日本實驗大鼠、小鼠
 
疾病模式動物
 
 

 NSY/Hos  Mouse model of type 2 diabetes

                                      

 

Proper name

NSY/Hos

Description

 

NSY小鼠依年齡會自發形成糖尿病,其48週齡時累計發病率公鼠98%、母鼠31%。在任何年齡,均無重度肥胖或極端胰島素血症發現。24週齡後,葡萄糖刺激胰島素分泌顯著不良。

NSY小鼠與人類二型糖尿病(非胰島素依賴型)極為相似,例如發病是年齡依賴性、動物無重度肥胖、胰島素抗性和胰島素對葡萄糖反應不良均會助長疾病發生。 

 NSY mice spontaneously develop diabetes mellitus in an age-dependent manner. The cumulative incidence of diabetes is 98% in males and 31% in females at 48 weeks of age. Neither severe obesity nor extreme hyperinsulinaemia is observed at any age in these mice. Glucose-stimulated insulin secretion was markedly impaired in NSY mice after 24 weeks of age. [1]
 NSY mouse closely mimics human Type II (non-insulin-dependent) diabetes mellitus in that the onset is age-dependent, the animals are not severely obese, and both insulin resistance and impaired insulin response to glucose contribute to disease development. [2]

Reseach

糖尿病二型

Type 2 diabetes

Development

 The NSY Nagoya-Shibata-Yasuda mouse was established as an inbred strain of mouse with spontaneous development of diabetes mellitus, by selective breeding for glucose intolerance from outbred Jcl:ICR mice. [1] To Hoshino Laboratory Animals, Inc. from Osaka University in 2002 at F55.

Attention

Breeding is prohibited.

 

 

Reference

[1] Ueda, H. et al. The NSY mouse: a new animal model of spontaneous NIDDM with moderate obesity. Diabetologia 38, 503–508 (1995).

[2] 
Ueda, H. et al. Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse. Diabetologia 43, 932–8 (2000).

 
 
 
關於太和實驗動物實驗儀器設備飼育管理儀器手術解剖器具美國WPI產品聯絡我們首頁