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Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  agouti (A,B,hi)
Inbred Generations  F143+62 (09.5.29)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected  
Origin NIH (1988, F143) > Kyo (F43)
Strain characteristics Spontaneous tumours 46% testes,16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21% pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females. Other conditions include 28% of males and 20% of females with absent, hypoplastic or cystic kidneys on one side sometimes associated with an absent or defective uterine horn or atrophic testes on the same side (Maekawa and Odashima 1975). These abnormalities have a polygenic mode of inheritance (Cramer and Gill 1975).
Breeding Conditions Usually good breeding performance but reduce litter size in case of females with agenesis of the uterine horn.
Genotyping  
References 1: Related Articles, LinksShull JD, Lachel CM, Strecker TE, Spady TJ, Tochacek M, Pennington KL, Murrin CR, Meza JL, Schaffer BS, Flood LA, Gould KA.
Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14.
Mamm Genome. 17(7):751-9, 2006.
Additional strain information ACI  

 
 
 
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