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Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
From a closed but not inbred colony of Sprague Dawley (SD) rats in the laboratory animal facilities of the Universitat Autónoma de Barcelona (Bellaterra Campus) in 1991. Via Institute Pasteur, Paris, to Kyoto University (1996).
Strain characteristics
An autosomal recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation recessive maps to rat Chromosome (Chr) 17. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human (Kuramoto et al. 1996).
Breeding Conditions
Maintained in heterozygous condition.
Genotyping
References
Kuramoto T, Sotelo C, Yokoi N, Serikawa T, Gonalons Sintes E, Canto Martorell J, Guenet J-L.
A rat mutation producing demyelination (dmy) maps to chromosome 17.
Mamm Genome. 7: 890-894, 1996.
Kitada K. et al
Determination of the mouse homologous region for the rat dmy locus.
J Exp Anim. Sci. 41:40-43, 2000.
Kuwamura M, Kanehara T, Tokuda S, Kumagai D, Yamate J, Kotani T, Nakane Y, Kuramoto T, Serikawa T
Immunohistochemical and morphometrical studies on myelin breakdown in the demyelination (dmy) mutant rat.
Brain Res. 1;1022(1-2):110-6, 2004
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Segregating