Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI/Kyo. A second zi allele carrying line with WTC backgrund was established at Kyoto University WTC.ZI-zi.
Strain characteristics
vacuole formation, tremor
Breeding Conditions
Heterozygous female and homozygous male are mated.
Genotyping
8 bp deletion in intron 12 of Attractin gene
References
Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T, Serikawa T.
Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system.
Proc Natl Acad Sci USA, 98 (2): 559-564, 2001
Kuramoto T, Yamasaki K, Kondo A, Nakajima K, Yamada M, Serikawa T.
Production of WTC.ZI-zi rat congenic strain and its pathological and genetic analyses.
Exp Anim, 47: 75-81, 1998
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Inbred