Kobe university→Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1975→Hokkaido University, Center for Experimental Plants & Animals(Hok) 1982, F19. Long Evans Agouti derived originally from an outbred Long Evans stock at Hokkaido University and selected for agouti coat colour (though Long Evans stock is usually fixed for non-agouti, hooded genes).
Strain characteristics
The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). But LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat.
Breeding Conditions
Good breeding performance. Sib-mating.
Genotyping
References
Agui T, Miyamoto T, Tsumagari T
X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci.
Exp Anim. 50(2):147-51, 2001.