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Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  agouti (A,B,C,h)
Inbred Generations  F88+14 (07.7.31)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability    
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected  
Origin Kobe university→Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1975→Hokkaido University, Center for Experimental Plants & Animals(Hok) 1982, F19. Long Evans Agouti derived originally from an outbred Long Evans stock at Hokkaido University and selected for agouti coat colour (though Long Evans stock is usually fixed for non-agouti, hooded genes).
Strain characteristics The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). But LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat.
Breeding Conditions Good breeding performance. Sib-mating.
Genotyping  
References Agui T, Miyamoto T, Tsumagari T
X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci.
Exp Anim. 50(2):147-51, 2001.
Additional strain information LEA   

 
 
 
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