Spontanious mutation from LEW inbred at Osaka Prefecture University in 1992. A congenic strain was produced by backcrosses to F344/NSlc strain at Kyoto University.
Strain characteristics
Hereditary cerebellar vermis defect. Mutant rats exhibit hind-leg paralysis from about 14 days old. Gross pathology showes the cerebellar vermis defect, fused cerebellar hemispheres and cyst formation. Ectopic dysplastic cerebellar tissues exist in the cerebello-pontine junctional zones. Mild disarrangement of lamination was also observed in the fused cerebellar hemispheres (Kuwamura 1994).
Breeding Conditions
Good breeding performance. Sib mating between homorozygous female and heterozygous male.
Genotyping
References
Kuramoto T, Kuwamura M, Serikawa T.
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Brain Res Mol Brain Res. 122(2): 103-108, 2004.
Kuwamura M, Yoshida T, Yamate J, Kotani T, Sakuma S.
Hereditary cerebellar vermis defect in the Lewis rat.
Dev Brain Res. 83: 294-298, 1994.
Kuwamura M, Yoshida T, Ishida A, Tsudzuki M, Yamate J, Kotani T, Sakuma S.
Cerebellar vermis defect: a new neurological mutation in the rat.
J Hered. 87(2): 161-162, 1996.
Kuwamura M, Yoshida T, Yamate J, Kotani T, Sakuma S, Tsudzuki M.
Perivascular external granule cells in hereditary cerebellar vermis defect rat: pathogenesis of cerebellar cortical dysplasia.
J Vet Med Sci. 58(9): 875-879, 1996.
Kuwamura M, Ishida A, Yamate J, Kato K, Kotani T, Sakuma S.
Chronological and immunohistochemical observations of cerebellar dysplasia and vermis defect in the hereditary cerebellar vermis defect (CVD) rat.
Acta Neuropathol. 94: 549-556, 1997.
Kuwamura M, Shirota A, Yamate J, Kotani T, Sakuma S.
Analysis of aberrant neuronal migrations in the hereditary cerebellar vermis defect (CVD) rat using bromodeoxyuridine-immunohistochemistry.
Acta Neuropathol. 95: 143-148, 1998.
Kuwamura M, Morikawa T, Yamate J, Kato K, Kotani T, Sakuma S.
Glial pathology in development of cerebellar dysplasia in the hereditarycerebellar vermis defect (CVD) rat.
Acta Neuropathol. 99: 305-309, 2000.
Kuwamura M, Shirota A, Takada A, Yamate J, Kotani T, Sakuma S.
Spontaneous and ethyl-nitrosourea-induced medullomyoblastomas in cerebellarvermis defect (CVD) mutant rat.
Acta Neuropathol. 99: 285-288, 2000.
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Inbred