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Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Unc5c: unc-5 homolog C (C. elegans)
Origin
HOB rat was identified in the F344 congenic rats (N12F13) to which the coat color locus (C) of fatty rat has been transferred in Sankyo Co., Ltd. Introduced to Kyoto University in 1999 at F13.
Strain characteristics
Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus.
Breeding Conditions
Maintained in sib mating between hob/+ male and hob/hob female. Good breeding performance.
Genotyping
PCR-RFLP（see Kuramoto et al. Mol. Brain Res. 122(2): 103-108, 2004)
References
Kuwamura M, Ando Y, Takeda A, Kanehara T, Yamane J, Kotani T, Takeshita S, Kanbori M, Kitada, K, Serikawa, T.
Rat mutations cvd and hob with cerebellar malformations map to chromosome 2.
Exp. Anim. 53(1): 21-26, 2004.
Kuramoto T, Kuwamura M, Serikawa T.
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Brain Res Mol Brain Res. 122(2): 103-108, 2004.
Embryo /751a%20(Large).jpg)
/751z%20(Large).jpg)
Segregating