In publishing, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
ACI/N rats are susceptible and BUF/Nac rats are resistant to MNNG-induced stomach carcinogenesis, and the presence of an autosomal gene with a dominant BUF allele has been suggested. By using ACI x (ACIxBUF)F1 backcross rats, one dominant susceptibility gene, Gcs1 (Gastric cancer susceptibility gene 1), and three dominant resistance genes, Gcr1 (Gastric cancer resistance gene 1), Gcr2, and Gcr3 have been mapped by QTL analysis for MNNG-induced stomach carcinogenicity. This congenic strain is homozygous for the ACI/N Gcr1a allele (on chr.4) on the BUF/Nac background.
Strain characteristics
Breeding Conditions
Good breeding performance.
Genotyping
D4Rat192, D4Rat66
References
Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T, Nagao M.
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer Res, 60:1092-1096, 2000
Embryo 
Living Animals
