The LE/Stm rats were introduced into Saitama Cancer Center Research Institute in 1969 from a closed colony of Long Evans rats maintained in the Ben May Laboratory for Cancer Research, University of Chicago. A mutant with red-eyed dilution was found in 1970 in the Long-Evans colony, and the mutation was fixed by selective mating. Thereafter, they were maintained by sister-brother mating more than F50.
Strain characteristics
A parental strain of LEXF/FXLE RI strains (NBRP No.0105-0138).
Breeding Conditions
Good breeding performance. Sib mating.
Genotyping
References
Shisa H, Lu L, Katoh H, Kawarai A, Tanuma J, Matsushima Y, Hiai H.
The LEXF: a new set of rat recombinant inbred strains between LE/Stm and F344.
Mamm Genome. 1997 May;8(5):324-7.
Lu LM, Shisa H, Tanuma J, Hiai H.
Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis.
Br J Cancer. 1999 May;80(5-6):855-61.