Originated from analbuminemic rats found in the closed colony of SD (Jcl:SD).
Strain characteristics
Analbuminemia. Inherited as an autosomal recessive trait. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. No expression of serum albumin is due to skipping of the exon H caused by a mutation in the intron HI.
Breeding Conditions
Sib mating.
Genotyping
References
Nagase S, Shimamune K, Shumiya S.
Science. 1979 Aug 10;205(4406):590-1.
Albumin-deficient rat mutant.
Hitomi Y, Sugiyama K, Esumi H.
Suppression of the 5' splice site mutation in the Nagase analbuminemic rat with mutated U1snRNA.
Biochem Biophys Res Commun. 1998 Oct 9;251(1):11-6.