The user shall comply with the agreement written by Japan SLC, Inc.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Japan SLC, Inc
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Rgn: regucalcin
Origin
Rats were generated by pronuclear injection of the transgene with a cDNA construct encoding rat regucalcin, a regulatory protein of Ca2+ signaling (Yamaguchi, 2002). (09.11.5)
Strain characteristics
This transgenic strain shows overexpression of regucalcin. Animal model for bone disease as represented by bone loss. The body weight of tg rats is significantly lowered. (Yamaguchi, 2002) (09.11.5)
Breeding Conditions
Sib mating.
Genotyping
References
Yamaguchi M, Morooka Y, Misawa H, Tsurusaki Y, Nakajima R.
Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity.
J Cell Biochem. 2002;86(3):520-9.
Embryo 
Living Animals.jpg)
.jpg)
