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Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Gja8: gap junction membrane channel protein alpha 8
Origin
The UPL rat was founded as a mutant with cataracts in a colony of Crj:CD (SD) rats at Tsukuba Research Laboratory, Upjohn Pharmaceuticals Limited, (Ibaraki, Japan) in 1989 and was introduced to the research facilities for laboratory animal science at Hiroshima University School of Medicine in 1996. Upjohn Pharmaceuticals Limited (UPL) rat. (09.3.3)
Strain characteristics
Genetic analysis of the mutant showed that a single gene was semidominantly involved in the development of cataract. Homozygotes of UPL rats displayed early-onset cataract, which manifested as lens opacification before eye opening at 14 days of age and was often accompanied by microphthalmos and/or buphthalmos. Heterozygotes of UPL rats displayed late-onset cataract that started to appear at 2 to 4 weeks of age and developed into complete opacity of the lenses in both eyes (mature cataract) at 7 to 8 weeks of age. A candidate gene for formation of cataracts in UPL rats was mapped to rat chr 2, and a missense mutation (R340W) of the Cx50 (Gja8) gene was a strong candidate (Yamashita, 2002). (09.3.3)
Breeding Conditions
Maintained by rotation breeding of 3 groups (group A, B and C). Resulting heterozygoutes are used for breeding. Offspring born from group A×B are defined as group C, group B×C are defined as group A, group C×A are defined as group B.
Genotyping
References
Yamashita S, Furumoto K, Nobukiyo A, Kamohara M, Ushijima T, Furukawa T.
Mapping of A gene responsible for cataract formation and its modifier in the UPL rat.
Invest Ophthalmol Vis Sci. 43(10):3153-9, 2002.
Embryo 
Sperm 