In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature(s) designated by the DEPOSITOR is requested.(see References)
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
The DRH is an inbred rat strain established by selective breeding of the 3'-Me-DAB resistant progeny of closed colony Donryu rats over 20 generations. Genetic analysis shows that two semidominant QTLs, Drh1 and Drh2, are responsible for strong resistance to chemical-induced hepatocarcinogenesis in DRH rats. Inbred DRH and F344 rats were purchased from SEAC Yoshitomi Co. DRH.
Strain characteristics
Breeding Conditions
Sib mating.
Genotyping
References
Zeng ZZ, Higashi S, Kitayama W, Denda A, Yan Y, Matsuo K, Konishi Y, Hiai H, Higashi K.
Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats.
Cancer Res. 2000 Jun 1;60(11):2876-81.
Yan Y, Zeng ZZ, Higashi S, Denda A, Konishi Y, Onishi S, Ueno H, Higashi K, Hiai H.
Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage.
Carcinogenesis. 2002 Jan;23(1):189-96.
Liu H, Nobumoto K, Yamada Y, Higashi K, Hiai H.
Modulation of genetic resistance to hepatocarcinogenesis in DRH rats by partial hepatectomy.
Cancer Lett. 2003 Jun 30;196(1):13-6.
Higashi K, Hiai H, Higashi T, Muramatsu M.
Regulatory mechanism of glutathione S-transferase P-form during chemical hepatocarcinogenesis: old wine in a new bottle.
Cancer Lett. 2004 Jun 25;209(2):155-63.
Liu H, Higashi K, Hiai H.
Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain.
Cancer Sci. 2005 Mar;96(3):164-9.
Embryo 
Sperm 
