In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
Congenic BB.6S rats were established by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats in 2000.
Strain characteristics
Diabetes frequency is significantly decreased in comparison with parental BB/OK rats (15 vs. 86%).Animals are heavier and serum lipids are increased compared with BB/OK.
Breeding Conditions
Genotyping
References
Kloting I, Schmidt S and Kovacs P
Mapping of novel diabetes predisposing and protecting genes in the spontaneously diabetic BB/OK rat.
Biochem. Biophys. Res. Commun. 245, 1998, 483-486
Kloting, I., van den Brandt, J. and P. Kovacs
Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.
Int. J. Mol. Med. 2, 1998, 597-601
Kloting, I., van den Brandt, J. and B. Kuttler
Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: Lessons from congenic BB.SHR rat strains.
Biochem. Biophys. Res. Commun.283, 2001, 399-405
Embryo 
Sperm 