In publishing, a citation of the following literature designated by the DEPOSITOR is requested.
Fujita, O., Annen, Y., and Kitaoka, A. (1994) Tsukuba high- and low-emotional strains of rats (Rattus norvegicus): an overview. Behavior Genetics, 24, 389-415.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
In 1972, Fujita began selective breeding for differences in ambulatory activity in the runway test. Two strains have been separated from each other and established as inbred strains. The inactive strain was named the Tsukuba High-Emotional (THE, NBRP No.0270); the active one, the Tsukuba Low-Emotional (TLE, NBRP No.0271) (Fujita, 1984). (09.6.4)
Strain characteristics
The THE and TLE strains have been selected, respectively, for low and high activity in a runway test. During the course of selection, defecation has increased in the THE strain and decreased in the TLE strain. These strain differences were not affected by maternal influences, early experience, or psychotropic drugs. THE rats were consistently inactive in all novel situations examined, while TLEs were very active. The level of spontaneous activity, however, was similar between the two strains. It was remarkable that THE rats showed more burrowing activity than TLE animals, whereas the latter displayed more aggression than the former. Differences in learning ability, concentration of neural transmitters, and social behavior were examined (Fujita, 1994). (09.6.4)
Breeding Conditions
Originally individuals were selected for sib mating by the Runway Test, every generation until F35 and every 5th generation after F36 until F50. At present, they are maintained only by sib mating. The breeding is difficult because of filial cannibalism.
Annen, Y. & Fujita, O. 1984 Intermale aggression in rats selected for emotional reactivity and their reciprocal F1 and F2 hybrids. Aggressive Behavior, 10, 11-19.
Annen, Y. & Fujita, O. 1985 Relationship between emotionality of intruders and aggressive behavior of residents in rats. Japanese Psychological Research, 27, 119-124.
Annen, Y. & Fujita, O. 1985 Septal lesions and biting attacks in rats bidirectionally selected for emotionality. Behavioral and Neural Biology, 43, 132-142.
Fujii, M., Asada, M., Takata, N., Yamano, A. & Imada, H. 1989 Measurement of emotional reactivity and association ability of the Tsukuba emotional strains of rats (Rattus norvegicus) in licking and lever-pressing conditioned suppression situations. Journal of Comparative Psychology, 103, 100-108.
Imada, H. 1972 Emotional reactivity and conditionability in four strains of rats. Journal of Comparative and Physiological Psychology, 79, 474-480.
Iso, H., Brush, F.R., Fujii, M., & Imada, H. 1988 Running-wheel avoidance learning in rats (Rattus norvegicus): effects of contingencies and comparisons of different strains. Journal of Comparative Psychology, 102, 350-371.
Kitaoka, A. 1991 Emergence from home cage in rats(Rattus norvegicus) as a function of strain and sex. Japanese Journal of Animal Psychology, 41, 28-33.
Kitaoka, A. & Fujita, 0. 1991 Behavioral comparisons of the Tsukuba Emotional strains of rats (Rattus norvegicus) in three types of novel situations. Behavior Genetics, 21, 317-325.
Kitaoka, A. 1994 Defensive aspects of burrowing behavior in rats (Rattus norvegicus) : A descriptive and correlational study. Behavioural Processes, 31, 13-28.
Nageishi,Y. & Imada, H. 1974 Suppression of licking behavior in rats as a function of predictability of shock and probability of conditioned-stimulus-shock pairings. Journal of Comparative and Physiological Psychology, 87, 1165-1173.
Naito, H., Inoue, M., & Makino, J. 2000 Ultrasonic isolation calls in genetically high- and low-emotional rat pups. Experimental Animals, 49, 289-294.
Naito, H., Inoue, M., Suzuki, Y., Tohei, A., Watanabe, G., Taya, K. & Makino, J. 2001 Ultrasonic vocalization responses in genetically high- and low-emotional rats. Experimental Animals, 50, 285-291.
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