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Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
HSVtk: herpes simplex virus thymidine kinase
Origin
This strain was established at Jichi Medical School.
Strain characteristics
This strain expresses HSVtk (herpes simplex virus thymidine kinase) liver-specific driven by mouse albumin enhancer/promoter. Administration of injection ganciclovir (GCV) in this transgenic rats causes hepatitis.
Breeding Conditions
Male infertility.
Genotyping
References
Kawasaki M, Fujino M, Li XK, Kitazawa Y, Funeshima N, Takahashi R, Ueda M, Amano T, Hakamata Y, Kobayashi E.
Inducible liver injury in the transgenic rat by expressing liver-specific suicide gene.
Biochem Biophys Res Commun. 28;311(4):920-8, 2003.
Embryo 
Sperm 