ZFDM rats (Hos:ZFDM-Leprfa, fa/fa and fa/+)
Rat model of type 2 diabetes
Efficient Breeding and Low Price
Characteristics of the ZFDM and ZDF strains. [1]
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ZFDM
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ZDF
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Origin
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ZF colony at Tokyo Medical University
(Tokyo, Japan)
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ZF colony at Eli Lilly Research Laboratories (Indianapolis, IN)
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Genetic control
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遠交系 Outbred
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近交系 Inbred
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Obesity*
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早期發生肥胖 (6-12週)
Early onset (6-12wk)
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早期發生肥胖(6-10週)
Early onset (6-10wk)
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Diabetes*
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早/中期發生糖尿病
Young to middle age-onset (10-20wk)
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早期發生糖尿病
Young age-onset (8-12wk)
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Special diet
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不須特殊飼料
Not needed
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Purina 5008
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Breeding
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♀(fa/+) × ♂(fa/fa)
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♀(fa/+) × ♂(fa/+)
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*Characteristics of fa/fa male rats in the ZFDM and ZDF strains.
[1] Yokoi, N. et al. A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat. J. Diabetes Res. 2013, 103731 (2013).
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