Hos:HR/DeF1 Melanin-possessing hairless mice
(HR-1 × HR/DE) F1 hairless mice
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Proper name
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Hos:(HR-1×HR/De)F1
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Description
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同型合子突變(Hrhr/Hrhr)，第一毛髮週期正常生長，二週齡因第二毛髮週期異常，開始快速掉毛。離乳期（約三週齡）完全無毛。
Homozygous mutants (Hrhr/Hrhr) show normal development of the first hair coat (first hair cycle). Starting at 2 weeks of age, they lose their hair coat rapidly and completely due to an abnormal second hair cycle [1, 2]. At weaning (~3 weeks of age), they are completely hairless [3].
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Appearance
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pigmented, without hair, unaffected
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Genotype
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Hrhr/Hrhr
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Reseach
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紫外線照射誘發黑色素生成
ultraviolet radiation induced melanogenesis
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Development
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We stareted to cross HR/De male mice to HR-1/Hos female mice in 2009. We named them Hos:HR/DeF1.
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Attention
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Breeding is prohibited.
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Reference
[1] Brooke, H.C. 1926. Hairless mice. J. Hered. 17, 173–174.
[2] Sundberg, J. P. & King, L. E. Morphology of hair in normal and mutant laboratory mice. Eur. J. Dermatol. 11, 357–61
[3] Suzuki, O., Koura, M., Noguchi, Y., Uchio-Yamada, K. & Matsuda, J. Zygosity determination in hairless mice by PCR based on Hr(hr) gene analysis. Exp. Anim. 62, 267–73 (2013). |
