NSY/Hos Mouse model of type 2 diabetes
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Proper name
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NSY/Hos
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Description
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NSY小鼠依年齡會自發形成糖尿病，其48週齡時累計發病率公鼠98%、母鼠31%。在任何年齡，均無重度肥胖或極端胰島素血症發現。24週齡後，葡萄糖刺激胰島素分泌顯著不良。
NSY小鼠與人類二型糖尿病（非胰島素依賴型）極為相似，例如發病是年齡依賴性、動物無重度肥胖、胰島素抗性和胰島素對葡萄糖反應不良均會助長疾病發生。
NSY mice spontaneously develop diabetes mellitus in an age-dependent manner. The cumulative incidence of diabetes is 98% in males and 31% in females at 48 weeks of age. Neither severe obesity nor extreme hyperinsulinaemia is observed at any age in these mice. Glucose-stimulated insulin secretion was markedly impaired in NSY mice after 24 weeks of age. [1]
NSY mouse closely mimics human Type II (non-insulin-dependent) diabetes mellitus in that the onset is age-dependent, the animals are not severely obese, and both insulin resistance and impaired insulin response to glucose contribute to disease development. [2]
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Reseach
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糖尿病二型
Type 2 diabetes
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Development
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The NSY （Nagoya-Shibata-Yasuda） mouse was established as an inbred strain of mouse with spontaneous development of diabetes mellitus, by selective breeding for glucose intolerance from outbred Jcl:ICR mice. [1] To Hoshino Laboratory Animals, Inc. from Osaka University in 2002 at F55.
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Attention
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Breeding is prohibited.
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Reference
[1] Ueda, H. et al. The NSY mouse: a new animal model of spontaneous NIDDM with moderate obesity. Diabetologia 38, 503–508 (1995).
[2] Ueda, H. et al. Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse. Diabetologia 43, 932–8 (2000). |
