db mouse（C57BLKS/J Iar -+Lepr^db/+Lepr^db）

非胰島素依賴型糖尿病 / Model animal for non-insulin-dependent diabetes mellitus

起源

db小鼠 (C57BLKS/J Iar -+Lepr^db/+Lepr^db)在1985年自濱松醫科大學引入IAR。

毛皮顏色

db/db (homo)和m+/db(herero)：黑色

m+/m+ (misty)：灰色

特色

此品系動物為非胰島素依賴型（NIDDM, non-insulin-dependent diabetes mellitus)，和人類肥胖型糖尿病症狀相似。Leptin receptor異常導致暴食和肥胖。同型合子(homo)小鼠3-4週齡開始顯現體重和血糖水平增加。加入遺傳標誌Lepr^db因致病基因使leptin receptor異常。

db mouse（C57BLKS/J Iar -+Lepr^db/+Lepr^db）

Model animal for non-insulin-dependent diabetes mellitus

Origin
db mouse, C57BLKS/J Iar -+Leprdb/+Leprdb, is introduced to the Institute for Animal Reproduction from Hamamatsu University School of Medicine in 1985.

Coat color
db/db (homo) and m+/db (hetero): Black
m+/m+ (misty): Gray

Characteristics

This shows overeating and obesity caused by abnormality of the leptin receptor. Homo mouse indicates increases of weight and blood glucose level after three to four weeks of its birth. Genetic symbol, Leprdb, is added since causational gene is abnormality of the leptin receptor.