Inbred Rat

Long-Evans Cinnamon (LEC)

LEA

起源

神戶大學發現Long Evans品系，北海道大學近親配種＞大塚製藥＞德島大學＞2007年引入IAR。

毛皮顏色

LEC：Cinnamon coat color

LEA：Agouti coat color

特色

LEC：

• 自發性急性肝炎、
• 存活超過1年以上的個體幾乎均有肝細胞癌發生、
• 銅代謝異常、
• 輔助T細胞缺乏症、
• X光高感受性
  

研究用途

LEC：肝炎、肝癌、威爾森氏症Wilson's disease

LEA：LEC大鼠的對照品系

Origin
Found in Long Evans strain at Kobe University > Inbreeding at Hokkaido University > Otsuka Pharmaceutical Co. > The University of Tokushima > Institute for Animal Reproduction 2007

Coat Color
Cinnamon-like

Characteristics
• Hepatitis and jaundice 1)

Research Use
• Liver cancer 2) and Wilson’s disease 3)

References
1) The LEC rat: a model for human hepatitis, liver cancer, and much more.  M. Mori, A. Hattori, M. Sawaki, N. Tsuzuki, N. Sawada, M. Oyamada, N. Sugawara, and K. Enomoto
2) The complete mitochondrial genome of a chronic hepatitis associated liver cancer LEC rat strain.  Zhang S1, Jiang Z, Zhang S, Xia M, Tian F, Tian H.
3) Early cell transplantation in LEC rats modeling Wilson's disease eliminates hepatic copper with reversal of liver disease. MalhiH1, IraniAN, VolenbergI, SchilskyML, Gupta S.